MRP- 600/-
CLF GOLD
(Joint Care Combination)
1. Glucosamine Sulphate – 700
mg
Class:
Amino sugar, naturally present in cartilage.
Mechanism:
• Stimulates glycosaminoglycan (GAG)
synthesis (building blocks of cartilage).
• Reduces breakdown of cartilage in
osteoarthritis.
• Exhibits mild anti-inflammatory effect.
Uses:
• Osteoarthritis, joint pain, cartilage
degeneration.
• Evidence: Multiple clinical trials show it
reduces pain and improves mobility,
especially in knee osteoarthritis.
• Limitations: Works slowly (effect after 4–6
weeks).
2. Collagen Peptide Type II – 40
mg
Class: Structural protein of cartilage.
Mechanism:
• Provides building blocks for cartilage
regeneration.
• Type II collagen maintains joint cushioning
and flexibility.
• May modulate immune response against
joint cartilage.
Uses:
Osteoarthritis, rheumatoid arthritis.
Joint stiffness & sports injuries.
• Evidence: Improves cartilage thickness &
reduces joint pain.
3. Chondroitin Sulphate – 100 mg
Class: Sulphated glycosaminoglycan,
component of cartilage.
Mechanism:
• Inhibits enzymes that destroy cartilage
(elastase, hyaluronidase).
• Retains water in cartilage → better shock
absorption.
Uses:
Osteoarthritis (slows progression).
Evidence: Works synergistically with
glucosamine, effective in long-term joint
protection.
4. Methyl Sulphonyl Methane
(MSM) – 50 mg
Class: Organic sulphur compound.
Mechanism:
• Provides sulphur for collagen and keratin
synthesis.
• Reduces oxidative stress & inflammation in
joints.
Uses:
Joint pain, stiffness, muscle soreness.
Evidence:
Improves flexibility and reduces swelling in
osteoarthritis patients.
5. Rosehip Extract – 275 mg
• Source: Fruit of Rosa canina.
• Active compounds: Polyphenols, vitamin C,
Galactolipids.
Mechanism:
• Anti-inflammatory & antioxidant.
• Inhibits COX and LOX enzymes (similar to
mild NSAIDs).
Uses:
• Osteoarthritis, rheumatoid arthritis.
• Supports immunity & skin health (due to
vitamin C).
Evidence:
Clinical studies show reduced pain and
decreased use of rescue painkillers in
osteoarthritis.
6. Ginger Extract – 50 mg
• Source: Zingiber officinale rhizome.
• Active compound: Gingerols, shogaols.
• Mechanism:
• Natural COX-2 inhibitor → reduces
inflammation.
• Improves blood circulation to joints.
Uses:
• Arthritis pain, morning stiffness.
• Evidence:
As effective as ibuprofen in mild
osteoarthritis for pain relief.
7. Boswellia Serrata – 100 mg
• Source: Indian frankincense (Salai guggul).
• Active compound:
Boswellic acids (esp. AKBA).
Mechanism:
• Inhibits 5-lipoxygenase pathway → reduces
leukotrienes (inflammatory mediators)
• Protects cartilage from degeneration.
Uses:
• Osteoarthritis, rheumatoid arthritis, asthma,
IBD.
• Evidence: Clinical studies show significant
reduction in knee pain & improved walking
distance in osteoarthritis patients.
8. Curcuma (Turmeric) Extract –
50 mg
• Source: Curcuma longa (turmeric).
• Active compound: Curcumin.
Mechanism:
• Potent anti-inflammatory (inhibits NF-κB,
COX-2).
• Strong antioxidant → prevents cartilage
damage.
Uses:
• Osteoarthritis, rheumatoid arthritis.
• Reduces stiffness and swelling.
Evidence:
Comparable to NSAIDs in OA pain
management but safer on stomach.
Overall Clinical Role of the
CLF-GOLD
• Indication:
Osteoarthritis, rheumatoid arthritis, sports
injuries, cartilage degeneration, chronic
joint pain.
Mechanism synergy:
• Glucosamine + Chondroitin + Collagen →
cartilage building & repair.
• MSM + Rosehip + Ginger + Boswellia +
Curcumin → anti-inflammatory &
antioxidant support.
Benefits:
• Reduces joint pain & stiffness.
• Improves flexibility & mobility.
• Slows progression of cartilage damage.
• Reduces need for NSAIDs (safer for
stomach/kidneys).
• Onset of Action:
Relief starts after 3–4 weeks, full benefits
after 2–3 months.
✅ Conclusion:
This combination is a multi-target therapy for joint health. It not only reduces pain & inflammation but also supports cartilage regeneration and long-term protection. It is especially beneficial in osteoarthritis, age-related joint issues, and sports injuries.
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