USOLE-D kid
1. Lansoprazole – 15 mg
Class:
• Proton Pump Inhibitor (PPI).
Mechanism of Action:
• Blocks H+/K+ ATPase (proton pump) in
gastric parietal cells.
• Inhibits final step of acid secretion → profound reduction in gastric acid.
• Works irrespective of stimulus (histamine,
acetylcholine, gastrin).
Pharmacokinetics:
• Absorption: Well absorbed orally, enteric-
coated formulation needed (acid-labile).
• Onset: Within 1–2 hours, peak at 3–4 hours.
• Half-life: 1.5 hours, but effect lasts 24 hours
(irreversible enzyme inhibition).
• Metabolism: Liver (CYP2C19, CYP3A4).
Indications:
• Gastroesophageal reflux disease (GERD).
• Peptic ulcer disease.
• Zollinger-Ellison syndrome (hypersecretory
conditions).
• H. pylori eradication (in combination with
antibiotics).
Adverse Effects:
Common:
Headache, Diarrhea, abdominal pain.
Long-term use:
• Vitamin B12, magnesium deficiency.
• Increased risk of osteoporosis (fractures).
• Possible kidney disease.
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2. Domperidone – 5 mg
Class:
• Peripheral dopamine D2 receptor antagonist
(prokinetic + antiemetic).
Mechanism of Action:
• Blocks dopamine D2 receptors in
chemoreceptor trigger zone (CTZ) →
antiemetic.
• Increases release of acetylcholine in gut →
enhances gastric motility.
• Accelerates gastric emptying and esophageal
peristalsis.
• Increases tone of lower esophageal sphincter
→ prevents reflux.
• Does not cross blood-brain barrier
significantly (so fewer CNS side effects vs
metoclopramide).
Pharmacokinetics:
• Absorption: Oral, best before meals.
• Metabolism: Liver (CYP3A4).
• Half-life: 7–9 hours.
Indications:
• Nausea and vomiting (due to drugs, GI
disorders).
• Dyspepsia, bloating, reflux.
• Adjuvant with PPIs in GERD and gastritis.
Adverse Effects:
• Common: Dry mouth, abdominal cramps.
• Rare: Breast tenderness, galactorrhea (due to prolactin increase).
• Cardiac: May prolong QT interval (risk of arrhythmia, esp. with higher doses).
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USOLE-D kid
(Lansoprazole 15 mg + Domperidone 5 mg)
Rationale:
• Lansoprazole: Reduces gastric acid secretion.
• Domperidone: Improves gastric emptying +
prevents reflux + controls nausea.
Together, they:
• Relieve heartburn, acidity, bloating.
• Reduce regurgitation in GERD.
• Heal ulcers and protect esophagus.
Indications of USOLE-D kid
• Gastroesophageal reflux disease (GERD).
• Dyspepsia with bloating, nausea.
• Peptic ulcer with reflux symptoms.
• Gastritis with acid-peptic complaints.
Advantages:
• Dual action: Acid suppression + motility
improvement.
• Symptomatic relief faster than PPI alone.
• Useful in GERD patients with nausea/
vomiting.
Limitations:
• Domperidone safety concerns at higher doses
(>30 mg/day) due to cardiac risk.
• Long-term PPI use risks (bone, B12,
magnesium deficiency).
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✅ Conclusion:
USOLE-D kid is a rational combination for acid-peptic disorders and GERD, especially when acid suppression + motility correction are needed together. Lansoprazole suppresses acid secretion effectively, while Domperidone prevents reflux, speeds gastric emptying, and controls nausea. Careful use is required in patients with cardiac risk (due to Domperidone) and for long-term PPI therapy.
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